Basal-like breast cancer tumors

GEO Description :
Analysis of sporadic basal-like cancer (BLC), BRCA-associated breast cancer, and non-BLC tumors. Sporadic BLC are phenotypically similar to BRCA1-associated cancers. Results provide insight into the molecular pathogenesis of BLC and BRCA1-associated breast cancer.
Organism : Homo sapiens
GEO-ID : GDS2250

Compared Group :

normal Vs basal-like cancer

• Number of Nodes in the Network : 25
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.83441421774955e-11
• Fold Change Cut-Off : 2.34

Compared Group :

normal Vs BRCA1-associated cancer

• Number of Nodes in the Network : 35
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 5.95292613070342e-06
• Fold Change Cut-Off : 2.14

Compared Group :

normal Vs non-basal-like cancer

• Number of Nodes in the Network : 46
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 3.29966193257647e-11
• Fold Change Cut-Off : 2.3

  Tamoxifen effect on normal endometrial epithelium

GEO Description :
Analysis of normal endometrial epithelial cells following treatment with oestrogen or tamoxifen (TMX). Results provide insight into the molecular basis of the association of TMX treatment of breast cancer with an increased incidence of endometrial cancer.
Organism : Homo sapiens
GEO-ID : GDS1510

Compared Group :

control Vs oestrogen

• Number of Nodes in the Network : 4
• Number of Nodes passing Cut-Off : 42
• PValue Cut-Off : 0.00042445765575394
• Fold Change Cut-Off : 2.78

Compared Group :

control Vs tamoxifen

• Number of Nodes in the Network : 51
• Number of Nodes passing Cut-Off : 98
• PValue Cut-Off : 0.00313237821683288
• Fold Change Cut-Off : 2.03

  Antiestrogen and aromatase inhibitor effect on breast cancer cells

GEO Description :
Analysis of estrogen receptor positive, aromatase transfected MCF-7 cells after treatment with an antiestrogen (AE) or an aromatase inhibitor (AI). AEs and AIs are used to treat estrogen-dependent breast cancer. Cells also treated with androgen which is converted to estrogen by aromatase.
Organism : Homo sapiens
GEO-ID : GDS1873

Compared Group :

control Vs antiestrogen treatment

• Number of Nodes in the Network : 23
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 2.84099442069419e-05
• Fold Change Cut-Off : 2.14

  Molecular apocrine breast tumors

GEO Description :
Analysis of tumors of 49 breast cancer patients. Tumors classified into luminal and basal classes, and a novel molecular apocrine class. Apocrine tumors are estrogen receptor negative (ER-) and androgen receptor positive (AR+), while luminal tumors are ER+ and AR+, and basal tumors are ER- and AR-.
Organism : Homo sapiens
GEO-ID : GDS1329

Compared Group :

apocrine tumor Vs basal tumor

• Number of Nodes in the Network : 25
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 5.20206516751998e-11
• Fold Change Cut-Off : 2.34

Compared Group :

apocrine tumor Vs luminal tumor

• Number of Nodes in the Network : 30
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 9.2198623735662e-11
• Fold Change Cut-Off : 2.18

Compared Group :

luminal tumor Vs basal tumor

• Number of Nodes in the Network : 29
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 7.57118331951725e-18
• Fold Change Cut-Off : 2.12

  Endoplasmic reticulum membrane-associated genes in breast cancer cell line MCF-7

GEO Description :
Identification of genes whose mRNA are translated from the endoplasmic reticulum (ER) in the breast cancer cell line MCF-7. Secreted and membrane-bound proteins are preferentially translated in the ER. Results provide insight into the association of membrane-bound proteins and breast cancer.
Organism : Homo sapiens
GEO-ID : GDS992

Compared Group :

membrane fraction Vs cytosolic fraction

• Number of Nodes in the Network : 34
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 7.13766712578945e-05
• Fold Change Cut-Off : 7.74