'Pathway Search Results'

Selection criteria for significant gene list :: Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.

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>>Total hits : 25 , Search term given : Diabetes

Type 1 diabetes mellitus model of erectile dysfunction

GEO Description :
Analysis of F344 penile cavernosal tissue after 10 weeks of streptozotocin (STZ)-induced Type 1 diabetes. Results provide insight into molecular events associated with pathophysiology of diabetes-induced erectile dysfunction (ED).
Organism : Rattus norvegicus
GEO-ID : GDS1393

Compared Group :
control Vs diabetes-induced erectile dysfunction

Number of Nodes in the Network : 31
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 2.54576589213684e-05
Fold Change Cut-Off : 2.91

Type 2 diabetes susceptibility: role of hepatic lipogenic capacity

GEO Description :
Analysis of adipose tissue, liver, skeletal muscle, and pancreatic islets from non-diabetic (C57BL/6J (B6)) and severely diabetic (BTBR) strains of obese (ob/ob), 14 week old males. Results correlate increased hepatic lipogenic gene expression in B6-ob/ob with type 2 diabetes resistance.
Organism : Mus musculus
GEO-ID : GDS1443

Compared Group :
adipose Vs pancreatic islet

Number of Nodes in the Network : 40
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.06375921404833e-06
Fold Change Cut-Off : 10.64

Compared Group :
adipose Vs soleus muscle

Number of Nodes in the Network : 37
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.81803682153259e-06
Fold Change Cut-Off : 7.95

Compared Group :
adipose Vs liver

Number of Nodes in the Network : 49
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 4.00871243755319e-07
Fold Change Cut-Off : 2.49

Compared Group :
liver Vs pancreatic islet

Number of Nodes in the Network : 35
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.52315919876855e-06
Fold Change Cut-Off : 22.52

Compared Group :
soleus muscle Vs pancreatic islet

Number of Nodes in the Network : 19
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 8.40265238366555e-06
Fold Change Cut-Off : 2.2

Compared Group :
liver Vs soleus muscle

Number of Nodes in the Network : 18
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.61500359752154e-08
Fold Change Cut-Off : 15.35

Exercise effect on the diabetic cardiac muscle: time course

GEO Description :
Analysis of experimental type 1 diabetic cardiac muscles of NMRI males subjected to endurance training for up to 5 weeks. Diabetes induced by a single peritoneal injection of streptozotocin.
Organism : Mus musculus
GEO-ID : GDS2335

Compared Group :
training Vs sedentary

Number of Nodes in the Network : 16
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 0.000410816981457174
Fold Change Cut-Off : 2.13

Compared Group :
healthy Vs diabetic

Number of Nodes in the Network : 53
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 2.05132582777878e-05
Fold Change Cut-Off : 2.14

Compared Group :
1 wk Vs 5 wk

Number of Nodes in the Network : 14
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 4.48429454991128e-05
Fold Change Cut-Off : 2.0

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The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.

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