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Analysis Pipeline


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Selection criteria for significant gene list :
Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.
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>>Total hits : 51 , Search term given : Glioma

  Gliomas of grades III and IV (HG-U133A)

GEO Description :
Analysis of grades III and IV gliomas of various histologic types. Results used to develop a gene-expression based, histology independent-classification scheme, and provide insight into the biology of gliomas.
Organism : Homo sapiens
GEO-ID : GDS1975

Compared Group :
grade IV glioma Vs grade III glioma
  • Number of Nodes in the Network : 51
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 5.78702974429746e-10
  • Fold Change Cut-Off : 2.07

  High-grade gliomas (HG-U133A)

GEO Description :
Analysis of high-grade glioma (HGGs) samples from cases of WHO grade III and IV astrocytomas. Results classify HGGs into molecular subclasses with prognostic value that predict survival and disease progression. The molecular subclasses resemble key stages of neurogenesis.
Organism : Homo sapiens
GEO-ID : GDS1815

Compared Group :
proneural Vs mesenchymal
  • Number of Nodes in the Network : 34
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 6.03866828018209e-18
  • Fold Change Cut-Off : 2.21
Compared Group :
primary Vs recurrent
  • Number of Nodes in the Network : 26
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 2.54602528002579e-05
  • Fold Change Cut-Off : 2.12
Compared Group :
proliferative Vs mesenchymal
  • Number of Nodes in the Network : 41
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 8.53954129631518e-11
  • Fold Change Cut-Off : 2.07
Compared Group :
proneural Vs proliferative
  • Number of Nodes in the Network : 28
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 1.31390294940209e-16
  • Fold Change Cut-Off : 2.3
Compared Group :
WHO grade III Vs WHO grade IV with necrosis
  • Number of Nodes in the Network : 31
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 6.28884657490692e-18
  • Fold Change Cut-Off : 2.11

  High-grade gliomas (HG-U133B)

GEO Description :
Analysis of high-grade glioma (HGGs) samples from cases of WHO grade III and IV astrocytomas. Results classify HGGs into molecular subclasses with prognostic value that predict survival and disease progression. The molecular subclasses resemble key stages of neurogenesis.
Organism : Homo sapiens
GEO-ID : GDS1816

Compared Group :
proneural Vs proliferative
  • Number of Nodes in the Network : 2
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 2.8549831769531e-12
  • Fold Change Cut-Off : 2.09
Compared Group :
WHO grade IV without necrosis Vs WHO grade IV with necrosis
  • Number of Nodes in the Network : 5
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 2.06720651476644e-05
  • Fold Change Cut-Off : 2.21
Compared Group :
less than 52 wk survival Vs more than 209 wk survival
  • Number of Nodes in the Network : 14
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 3.91972243960481e-05
  • Fold Change Cut-Off : 2.21

  Gliomas of grades III and IV (HG-U133B)

GEO Description :
Analysis of grades III and IV gliomas of various histologic types. Results used to develop a gene-expression based, histology independent-classification scheme, and provide insight into the biology of gliomas.
Organism : Homo sapiens
GEO-ID : GDS1976

Compared Group :
grade IV glioma Vs grade III glioma
  • Number of Nodes in the Network : 7
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 5.71420601808148e-12
  • Fold Change Cut-Off : 2.28







DISCLAIMER:
The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.

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