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Selection criteria for significant gene list :
Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.
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>>Total hits : 31 , Search term given : Hutchinson-Gilford AND Progeria AND Syndrome

  Hutchinson-Gilford progeria syndrome: fibroblast (HG-U133A)

GEO Description :
Expression profiling of three fibroblast cell lines derived from Hutchinson-Gilford progeria syndrome (HGPS) patients. Identified changes in gene expression may provide clues to potential risk factors or factors influencing disease progression.
Organism : Homo sapiens
GEO-ID : GDS1503

Compared Group :
normal Vs HGPS
  • Number of Nodes in the Network : 32
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 1.36823858909452e-08
  • Fold Change Cut-Off : 2.08
Compared Group :
AG11498 Vs GM0316B
  • Number of Nodes in the Network : 30
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000972020963672549
  • Fold Change Cut-Off : 2.19
Compared Group :
GM00038C Vs GM0316B
  • Number of Nodes in the Network : 30
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000577460392378271
  • Fold Change Cut-Off : 2.19
Compared Group :
AG11513 Vs GMO8398C
  • Number of Nodes in the Network : 29
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000769417325500399
  • Fold Change Cut-Off : 2.35
Compared Group :
GM00038C Vs GMO8398C
  • Number of Nodes in the Network : 23
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000487557612359524
  • Fold Change Cut-Off : 2.31
Compared Group :
AG11513 Vs GM00038C
  • Number of Nodes in the Network : 29
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000471004721475765
  • Fold Change Cut-Off : 2.02
Compared Group :
AG10750 Vs GM0316B
  • Number of Nodes in the Network : 39
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000137852824991569
  • Fold Change Cut-Off : 2.18

  Hutchinson-Gilford progeria syndrome: fibroblast (HG-U133B)

GEO Description :
Expression profiling of three fibroblast cell lines derived from Hutchinson-Gilford progeria syndrome (HGPS) patients. Identified changes in gene expression may provide clues to potential risk factors or factors influencing disease progression.
Organism : Homo sapiens
GEO-ID : GDS1504

Compared Group :
AG11498 Vs GM08398C
  • Number of Nodes in the Network : 12
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000789702811744064
  • Fold Change Cut-Off : 2.7
Compared Group :
AG11498 Vs GM0316B
  • Number of Nodes in the Network : 11
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000181541894562542
  • Fold Change Cut-Off : 2.16
Compared Group :
AG10750 Vs GM00038C
  • Number of Nodes in the Network : 8
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 2.21327336475952e-05
  • Fold Change Cut-Off : 2.2







DISCLAIMER:
The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.

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