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'Pathway Search Results'
- Selection criteria for significant gene list :
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Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.
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>>Total hits : 4
, Search term given : Hypoxia
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Hypoxia effect on B lymphocyte cell line
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GEO Description :
Expression profiling of B lymphocyte P493-6 cells subjected to hypoxia. Cells incubated in 0.1% oxygen for 29 hours, the point of highest expression of hypoxia-inducible factor 1 (HIF-1). Results identify hypoxia responsive genes in P493-6 cells.
Organism : Homo sapiens
GEO-ID : GDS1807
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- Compared Group :
- normoxia Vs hypoxia
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- Number of Nodes in the Network : 21
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 0.000138665476697497
- Fold Change Cut-Off : 2.23
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Hypoxia effect on HIF-1 alpha null hepatocytes
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GEO Description :
Analysis of hypoxia-inducible factor-1alpha (HIF-1alpha) null mutant hepatocytes subjected to hypoxic conditions for 8 hours. The HIF-1alpha transcription factor is a key regulator of oxygen homeostasis. Results provide insight into hepatocyte gene expression changes induced by short-term hypoxia.
Organism : Mus musculus
GEO-ID : GDS1648
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- Compared Group :
- normoxia Vs hypoxia
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- Number of Nodes in the Network : 43
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 1.84067939699162e-05
- Fold Change Cut-Off : 4.16
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- Compared Group :
- wild type Vs HIF-1 alpha null
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- Number of Nodes in the Network : 30
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 0.00343786063604057
- Fold Change Cut-Off : 2.41
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Intermittent hypoxia effect on liver
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GEO Description :
Examination of chronic intermittent hypoxia (CIH) effect on liver gene expression in leptin deficient (ob/ob) mice. CIH in the presence of pre-existent obesity may cause an increase in gene expression of enzymes of lipid biosynthesis. CIH is a component of obstructive sleep apnea (OSA).
Organism : Mus musculus
GEO-ID : GDS1213
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DISCLAIMER:
The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.
GeneSpring® is a registered trademark of Agilent Technologies.
GeneSpring® is developed on AVADIS™ from Strand Life Sciences
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