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Analysis Pipeline


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Selection criteria for significant gene list :
Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.
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>>Total hits : 89 , Search term given : Inflammation

  Angiotensin II type 1 receptor antagonist effect on brain microvessels of hypertensive animals

GEO Description :
Analysis of brain microvessels from hypertensive SHR males treated with candesartan, an angiotensin II type 1 receptor (AT1) antagonist, daily for 4 weeks. Blockade of angiotensin II AT1 receptors in cerebral microvessels protects against brain ischemia and inflammation.
Organism : Rattus norvegicus
GEO-ID : GDS2070

Compared Group :
control Vs candesartan
  • Number of Nodes in the Network : 42
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 1.94917652152071e-06
  • Fold Change Cut-Off : 2.21

  Endotoxin effect on leukocytes: time course (HG-U133A)

GEO Description :
Analysis of leukocytes from 8 healthy subjects intravenously administered bacterial endotoxin. Leukocytes examined at various time points up to 24 hours post-infusion. Results provide insight into the molecular mechanisms involved in the propagation and resolution of the inflammatory response.
Organism : Homo sapiens
GEO-ID : GDS1574

Compared Group :
subject 8 Vs subject 4
  • Number of Nodes in the Network : 48
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 6.26844638418333e-08
  • Fold Change Cut-Off : 2.24
Compared Group :
0 h Vs 9 h
  • Number of Nodes in the Network : 24
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 3.58080833393615e-05
  • Fold Change Cut-Off : 2.15
Compared Group :
subject 2 Vs subject 1
  • Number of Nodes in the Network : 34
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 1.45482099469518e-05
  • Fold Change Cut-Off : 2.4
Compared Group :
subject 4 Vs subject 3
  • Number of Nodes in the Network : 27
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 7.57586860800075e-07
  • Fold Change Cut-Off : 2.01

  Endotoxin effect on leukocytes: time course (U133 2.0)

GEO Description :
Analysis of leukocytes from 6 healthy subjects intravenously administered bacterial endotoxin. Leukocytes examined at various time points up to 6 hours post-infusion. Results provide insight into the molecular mechanisms involved in the propagation and resolution of the inflammatory response.
Organism : Homo sapiens
GEO-ID : GDS1579

Compared Group :
subject 1 Vs subject 5
  • Number of Nodes in the Network : 15
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.00102829246316105
  • Fold Change Cut-Off : 2.76

  Endotoxin effect on leukocytes: time course (HG-U133B)

GEO Description :
Analysis of leukocytes from 8 healthy subjects intravenously administered bacterial endotoxin. Leukocytes examined at various time points up to 24 hours post-infusion. Results provide insight into the molecular mechanisms involved in the propagation and resolution of the inflammatory response.
Organism : Homo sapiens
GEO-ID : GDS1576

Compared Group :
0 h Vs 6 h
  • Number of Nodes in the Network : 11
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 0.000316222984110937
  • Fold Change Cut-Off : 2.01
Compared Group :
subject 8 Vs subject 5
  • Number of Nodes in the Network : 16
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 6.03872436499842e-08
  • Fold Change Cut-Off : 2.67
Compared Group :
subject 3 Vs subject 5
  • Number of Nodes in the Network : 14
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 3.01936847790785e-06
  • Fold Change Cut-Off : 2.04
Compared Group :
subject 8 Vs subject 6
  • Number of Nodes in the Network : 15
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 1.01775976872887e-05
  • Fold Change Cut-Off : 2.77







DISCLAIMER:
The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.

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