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'Pathway Search Results'
- Selection criteria for significant gene list :
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Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.
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>>Total hits : 10
, Search term given : Lung AND Cancer
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Various lung cancer cell lines
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GEO Description :
Expression profiling of a set of 29 lung cancer cell lines consisting of 10 non-small cell adenocarcinoma, 10 small cell cancer, and 9 squamous cell cancer lines. Gene expression results analyzed in relation to the sensitivity of each cell line to commonly used anti-cancer agents.
Organism : Homo sapiens
GEO-ID : GDS1688
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- Compared Group :
- squamous cell cancer Vs small cell cancer
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- Number of Nodes in the Network : 45
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 4.57951182397665e-06
- Fold Change Cut-Off : 2.12
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- Compared Group :
- non-small cell adenocarcinoma Vs small cell cancer
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- Number of Nodes in the Network : 36
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 1.42541457535117e-05
- Fold Change Cut-Off : 2.11
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- Compared Group :
- non-small cell adenocarcinoma Vs squamous cell cancer
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- Number of Nodes in the Network : 15
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 4.20516698795836e-05
- Fold Change Cut-Off : 2.0
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Lung cancer cell line response to motexafin gadolinium: time course
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GEO Description :
Expression profiling of lung cancer cell line A549 following treatment with 50 uM of the metal cation-containing chemotherapeutic drug motexafin gadolinium (MGd). Cells examined at 4, 12, and 24 hours following treatment. Results provide insight into the mechanism of action of MGd.
Organism : Homo sapiens
GEO-ID : GDS1204
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- Compared Group :
- control Vs motexafin gadolinium
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- Number of Nodes in the Network : 22
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 3.48204614352755e-15
- Fold Change Cut-Off : 2.13
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- Compared Group :
- 12 h Vs 24 h
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- Number of Nodes in the Network : 25
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 0.001065434073098
- Fold Change Cut-Off : 2.11
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- Compared Group :
- 24 h Vs 4 h
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- Number of Nodes in the Network : 28
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 0.00323968683369458
- Fold Change Cut-Off : 2.01
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- Compared Group :
- 12 h Vs 4 h
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- Number of Nodes in the Network : 10
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 0.00192268542014062
- Fold Change Cut-Off : 2.1
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Urethane-induced lung tumor model of pulmonary adenocarcinoma
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GEO Description :
Analysis of lung tumors that develop following treatment with urethane. Urethane-induced lung tumors exhibit similar histological appearance and molecular changes to human pulmonary adenocarcinoma (AC). Results compared with those from human AC (GDS1650).
Organism : Mus musculus
GEO-ID : GDS1649
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- Compared Group :
- adjacent normal Vs tumor
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- Number of Nodes in the Network : 31
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 2.80576573967593e-21
- Fold Change Cut-Off : 2.26
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- Compared Group :
- 24 to 26 wk (early) Vs 42 wk (late)
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- Number of Nodes in the Network : 31
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 2.92948906235532e-13
- Fold Change Cut-Off : 2.09
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Pulmonary adenocarcinoma
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GEO Description :
Analysis of pulmonary adenocarcinomas (AC). Carcinogen exposure is responsible for the majority of ACs. Results compared with those obtained from a urethane-induced lung tumor model in the mouse (GDS1649), and provide insight into the conserved pathways underlying the development of AC.
Organism : Homo sapiens
GEO-ID : GDS1650
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- Compared Group :
- adjacent normal Vs tumor
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- Number of Nodes in the Network : 58
- Number of Nodes passing Cut-Off : 100
- PValue Cut-Off : 5.92806860745559e-17
- Fold Change Cut-Off : 2.27
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DISCLAIMER:
The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.
GeneSpring® is a registered trademark of Agilent Technologies.
GeneSpring® is developed on AVADIS™ from Strand Life Sciences
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