'Pathway Search Results'

Selection criteria for significant gene list :: Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.

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>>Total hits : 27 , Search term given : Lung AND Injury

Ventilator-induced lung injury (mouse)

GEO Description :
Investigation of deleterious effects of mechanical ventilation (MV) on lung gene expression in model of ventilator-induced lung injury. MV, a treatment of acute lung injury, can augment injury in some patients.
Organism : Mus musculus
GEO-ID : GDS1240

Compared Group :
control Vs ventilator-induced lung injury

Number of Nodes in the Network : 47
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 0.000622425810433924
Fold Change Cut-Off : 2.54

Ventilator-induced lung injury (rat)

GEO Description :
Investigation of deleterious effects of mechanical ventilation (MV) on lung gene expression in model of ventilator-induced lung injury. MV, a treatment of acute lung injury, can augment injury in some patients.
Organism : Rattus norvegicus
GEO-ID : GDS1241

Compared Group :
control Vs ventilator-induced lung injury

Number of Nodes in the Network : 30
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 9.85358274192549e-05
Fold Change Cut-Off : 2.02

Inflammatory lung injury and effect of simvastatin

GEO Description :
Analysis of effect of simvastatin in LPS-induced inflammatory model of acute lung injury. Male C57BL/6J administered simvastatin 24 hours prior to and concomitant with LPS. Simvastatin is a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor that mediates endothelial cell barrier protection.
Organism : Mus musculus
GEO-ID : GDS1239

Compared Group :
control Vs LPS-induced acute lung injury

Number of Nodes in the Network : 53
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 0.00262328912504017
Fold Change Cut-Off : 2.02

Compared Group :
control Vs simvastatin

Number of Nodes in the Network : 18
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 0.0258525069802999
Fold Change Cut-Off : 2.05

Alveolar epithelial cell line A549 response to acute lung injury causing stimuli: time course

GEO Description :
Examination of alveolar epithelial A549 cells in models of pulmonary parenchymal cell activation: exposure to tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS), or cyclic stretch. Cells examined 1 and 4 hours after exposure to each acute lung injury-causing stimulus.
Organism : Homo sapiens
GEO-ID : GDS852

Compared Group :
control Vs lipopolysaccharide

Number of Nodes in the Network : 47
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 0.00206801644526422
Fold Change Cut-Off : 2.15

Alveoli destruction time course

GEO Description :
Temporal study of lung alveoli destruction induced by caloric restriction. Alveoli number and surface area are linked to oxygen consumption, and calorie restriction lowers oxygen consumption.
Organism : Mus musculus
GEO-ID : GDS241

Compared Group :
control Vs calorie restricted

Number of Nodes in the Network : 39
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 0.00247963843867183
Fold Change Cut-Off : 2.3

Sulfur mustard effect on lungs: dose response and time course

GEO Description :
Analysis of lungs from Sprague Dawley males following injection with 1, 3, or 6 mg/kg of sulfur mustard (SM) bis-(2-chloroethyl) sulfide, a carcinogenic alkylating agent. Lungs examined at various time points up to 24 hours postinjection. Results provide insight into SM-induced lung injury.
Organism : Rattus norvegicus
GEO-ID : GDS1027

Compared Group :
24 h Vs 0.5 h

Number of Nodes in the Network : 34
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 9.50497479660327e-14
Fold Change Cut-Off : 2.27

Compared Group :
6 h Vs 3 h

Number of Nodes in the Network : 31
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.11209931219491e-06
Fold Change Cut-Off : 2.28

Compared Group :
6 h Vs 0.5 h

Number of Nodes in the Network : 34
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 9.8072781449729e-14
Fold Change Cut-Off : 2.32

Compared Group :
1 h Vs 3 h

Number of Nodes in the Network : 39
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 9.04487569641788e-06
Fold Change Cut-Off : 2.14

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The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.

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