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Analysis Pipeline


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Selection criteria for significant gene list :
Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.
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>>Total hits : 43 , Search term given : Myocardial AND Infarction

  Acute myocardial infarction model: time course (MG-U74A)

GEO Description :
Analysis of left heart ventricles (LV) at various time points up to 48 hours following surgically induced acute myocardial infarction (AMI). Ischemic/infarcted tissue, surviving free wall, and the interventricular septum of LV examined. Results provide insight into the molecular pathogenesis of AMI.
Organism : Mus musculus
GEO-ID : GDS2329

Compared Group :
sham Vs naive
  • Number of Nodes in the Network : 54
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 7.75113312556641e-06
  • Fold Change Cut-Off : 2.21
Compared Group :
left ventricle Vs interventricular septum
  • Number of Nodes in the Network : 38
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 5.5675402066413e-09
  • Fold Change Cut-Off : 2.1
Compared Group :
not applicable Vs 15 min
  • Number of Nodes in the Network : 40
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 4.95357971885824e-06
  • Fold Change Cut-Off : 2.14

  Acute myocardial infarction model: time course (MG-U74C)

GEO Description :
Analysis of left heart ventricles (LV) at various time points up to 48 hours following surgically induced acute myocardial infarction (AMI). Ischemic/infarcted tissue, surviving free wall, and the interventricular septum of LV examined. Results provide insight into the molecular pathogenesis of AMI.
Organism : Mus musculus
GEO-ID : GDS2331

Compared Group :
sham Vs naive
  • Number of Nodes in the Network : 3
  • Number of Nodes passing Cut-Off : 23
  • PValue Cut-Off : 0.000969494169112295
  • Fold Change Cut-Off : 2.0
Compared Group :
not applicable Vs 1 h
  • Number of Nodes in the Network : 4
  • Number of Nodes passing Cut-Off : 76
  • PValue Cut-Off : 2.59502048720606e-05
  • Fold Change Cut-Off : 2.19
Compared Group :
not applicable Vs 12 h
  • Number of Nodes in the Network : 7
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 4.65595212517655e-06
  • Fold Change Cut-Off : 2.16

  Acute myocardial infarction model: time course (MG-U74B)

GEO Description :
Analysis of left heart ventricles (LV) at various time points up to 48 hours following surgically induced acute myocardial infarction (AMI). Ischemic/infarcted tissue, surviving free wall, and the interventricular septum of LV examined. Results provide insight into the molecular pathogenesis of AMI.
Organism : Mus musculus
GEO-ID : GDS2330

Compared Group :
not applicable Vs 1 h
  • Number of Nodes in the Network : 6
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 6.148443389975e-07
  • Fold Change Cut-Off : 2.17
Compared Group :
surviving free wall Vs left ventricle
  • Number of Nodes in the Network : 12
  • Number of Nodes passing Cut-Off : 34
  • PValue Cut-Off : 0.00112425349652767
  • Fold Change Cut-Off : 2.09
Compared Group :
not applicable Vs 24 h
  • Number of Nodes in the Network : 13
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 6.85992986859674e-08
  • Fold Change Cut-Off : 2.07
Compared Group :
sham Vs naive
  • Number of Nodes in the Network : 10
  • Number of Nodes passing Cut-Off : 100
  • PValue Cut-Off : 2.20187303057173e-05
  • Fold Change Cut-Off : 2.0







DISCLAIMER:
The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.

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