Prostate cancer progression

GEO Description :
Expression profiling of prostate cancer tumors that are benign, clinically localized, or metastatic and refractory to hormones. Results compared to those obtained from immunoblotting to identify concordant changes in mRNA and protein levels.
Organism : Homo sapiens
GEO-ID : GDS1439

Compared Group :

primary Vs benign

• Number of Nodes in the Network : 25
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.79569653369072e-07
• Fold Change Cut-Off : 2.11

Compared Group :

primary Vs metastatic

• Number of Nodes in the Network : 32
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 6.33205043953922e-10
• Fold Change Cut-Off : 2.11

Compared Group :

benign Vs metastatic

• Number of Nodes in the Network : 25
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.53812448888679e-10
• Fold Change Cut-Off : 2.0

  Prostate cancer and mTOR inhibitors

GEO Description :
Analysis of prostate from transgenic mice expressing AKT (hyperactivated in some prostate cancers) treated with mammalian target of rapamycin (mTOR) inhibitor RAD001, and sacrificed after 12 or 48 hours. mTOR inhibition induced apoptosis and reverted a neoplastic phenotype in AKT-expressing prostate
Organism : Mus musculus
GEO-ID : GDS952

Compared Group :

placebo Vs RAD001

• Number of Nodes in the Network : 34
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 4.91629634780111e-08
• Fold Change Cut-Off : 2.04

Compared Group :

wild type Vs AKT transgenic

• Number of Nodes in the Network : 26
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.15338813794587e-17
• Fold Change Cut-Off : 2.25

Compared Group :

12 h Vs 48 h

• Number of Nodes in the Network : 16
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 0.000201503789867274
• Fold Change Cut-Off : 2.07

  Arachidonic acid effect on prostate cancer cells

GEO Description :
Analysis of PC-3 prostate cancer cells incubated with arachidonic acid (AA). AA is an omega-6 fatty acid shown to induce cancer cell proliferation. Results suggest AA plays an important role in stimulation of growth-related genes and proliferation via phosphatidylinositol 3-kinase (PI3K) signaling.
Organism : Homo sapiens
GEO-ID : GDS1736

Compared Group :

control Vs arachidonic acid

• Number of Nodes in the Network : 43
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 0.000134568414068781
• Fold Change Cut-Off : 2.02

  Androgen receptor modulator effect: time course (HG-U133A)

GEO Description :
Analysis of LNCaP cells treated for 6 and 24 hours with RTI-018, an androgen receptor (AR) ligand with a mechanism of action different from that of canonical agonists. Results provide insight into the link between RTI-018 induced AR conformational changes and its ability to regulate gene expression.
Organism : Homo sapiens
GEO-ID : GDS2057

Compared Group :

control Vs RTI-018

• Number of Nodes in the Network : 8
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 2.02323402476168e-08
• Fold Change Cut-Off : 2.08