Lung immune response to Nippostrongylus brasiliensis infection: time course

GEO Description :
Analysis of lungs of SCID animals at various time points up to 12 days post infection with Nippostrongylus brasiliensis. SCID animals have no functional B or T cells but a fully functional innate immune system. Results provide insight into the immune response to helminth infection in the lung.
Organism : Mus musculus
GEO-ID : GDS2024

Compared Group :

control Vs 3 dpi

• Number of Nodes in the Network : 41
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 9.01084092674864e-07
• Fold Change Cut-Off : 2.07

  siRNA knockdown and transcriptional response to DNA damage

GEO Description :
Analysis of HEK293 cells following siRNA knockdown of p53, RelA, or ATM, and subsequent treatment with neocarzinostatin, a radiomimetic drug that induces DNA double-strand breaks. Results indicate RNAi combined with expression profiling is a powerful method for dissecting transcriptional networks.
Organism : Homo sapiens
GEO-ID : GDS1852

Compared Group :

uninfected control Vs LacZ control

• Number of Nodes in the Network : 37
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.14124804895255e-06
• Fold Change Cut-Off : 2.14

Compared Group :

uninfected control Vs RelA knockdown

• Number of Nodes in the Network : 27
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 6.9023826654302e-08
• Fold Change Cut-Off : 2.04

Compared Group :

uninfected control Vs p53 knockdown

• Number of Nodes in the Network : 51
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 2.23944169874812e-07
• Fold Change Cut-Off : 2.03

Compared Group :

uninfected control Vs ATM knockdown

• Number of Nodes in the Network : 34
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.55796744394365e-08
• Fold Change Cut-Off : 2.12

Compared Group :

neocarzinostatin Vs untreated

• Number of Nodes in the Network : 50
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 3.92677384297713e-06
• Fold Change Cut-Off : 2.01

  Myotube response to PGC-1alpha induced mitochondrial biogenesis: time course (MG-U74C)

GEO Description :
Analysis of C2C12 myoblast-derived myotubes transduced with transcriptional coactivator PGC-1alpha to induce mitochondrial proliferation in the muscle cells. Cells examined up to 3 days post-transduction. Results combined with other genome-scale datasets to identify mitochondrial proteins.
Organism : Mus musculus
GEO-ID : GDS1880

Compared Group :

GFP control Vs untreated

• Number of Nodes in the Network : 7
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 9.29297493712511e-06
• Fold Change Cut-Off : 2.21

  Myotube response to PGC-1alpha induced mitochondrial biogenesis: time course (MG-U74A)

GEO Description :
Analysis of C2C12 myoblast-derived myotubes transduced with transcriptional coactivator PGC-1alpha to induce mitochondrial proliferation in the muscle cells. Cells examined up to 3 days post-transduction. Results combined with other genome-scale datasets to identify mitochondrial proteins.
Organism : Mus musculus
GEO-ID : GDS1878

Compared Group :

PGC-1alpha Vs GFP control

• Number of Nodes in the Network : 29
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.45328495904096e-08
• Fold Change Cut-Off : 2.05

Compared Group :

GFP control Vs untreated

• Number of Nodes in the Network : 43
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 2.40555976915857e-07
• Fold Change Cut-Off : 2.0

Compared Group :

PGC-1alpha Vs untreated

• Number of Nodes in the Network : 21
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 3.28640595625984e-07
• Fold Change Cut-Off : 2.06