Lung immune response to Nippostrongylus brasiliensis infection: time course

GEO Description :
Analysis of lungs of SCID animals at various time points up to 12 days post infection with Nippostrongylus brasiliensis. SCID animals have no functional B or T cells but a fully functional innate immune system. Results provide insight into the immune response to helminth infection in the lung.
Organism : Mus musculus
GEO-ID : GDS2024

Compared Group :

control Vs 3 dpi

• Number of Nodes in the Network : 41
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 9.01084092674864e-07
• Fold Change Cut-Off : 2.07

  Hereditary gingival fibromatosis

GEO Description :
Analysis of gingival tissues from a patient with hereditary gingival fibromatosis (HGF). HGF is a benign disorder characterized by a slow progressive enlargement of the gingiva. This hypertrophic overgrowth of the gingiva may completely cover the teeth.
Organism : Homo sapiens
GEO-ID : GDS1685

Compared Group :

normal Vs hereditary gingival fibromatosis

• Number of Nodes in the Network : 29
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 0.000424888712586835
• Fold Change Cut-Off : 2.12

  X-linked recessive dystonia-parkinsonism

GEO Description :
Expression profiling of the caudate nucleus and nucleus accumbens from the brain of a patient with X-linked recessive dystonia-parkinsonism (XDP). XDP is an adult onset disorder characterized by dystonia and parkinsonism. Result provide insight into the pathogenesis of XDP.
Organism : Homo sapiens
GEO-ID : GDS1912

Compared Group :

nucleus accumbens Vs caudate nucleus

• Number of Nodes in the Network : 35
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 0.000589361356105655
• Fold Change Cut-Off : 2.11

  Pterygium

GEO Description :
Expression profiling of primary pterygium tissue. Pterygium, a common ocular surface disorder, is a fibrovascular overgrowth from the conjunctiva onto the cornea. Results provide insight into pterygium pathogenesis.
Organism : Homo sapiens
GEO-ID : GDS1758

Compared Group :

pterygium Vs conjunctiva

• Number of Nodes in the Network : 50
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 9.94486399576999e-05
• Fold Change Cut-Off : 2.11

  siRNA knockdown and transcriptional response to DNA damage

GEO Description :
Analysis of HEK293 cells following siRNA knockdown of p53, RelA, or ATM, and subsequent treatment with neocarzinostatin, a radiomimetic drug that induces DNA double-strand breaks. Results indicate RNAi combined with expression profiling is a powerful method for dissecting transcriptional networks.
Organism : Homo sapiens
GEO-ID : GDS1852

Compared Group :

uninfected control Vs LacZ control

• Number of Nodes in the Network : 37
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.14124804895255e-06
• Fold Change Cut-Off : 2.14

Compared Group :

uninfected control Vs RelA knockdown

• Number of Nodes in the Network : 27
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 6.9023826654302e-08
• Fold Change Cut-Off : 2.04

Compared Group :

uninfected control Vs p53 knockdown

• Number of Nodes in the Network : 51
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 2.23944169874812e-07
• Fold Change Cut-Off : 2.03

Compared Group :

uninfected control Vs ATM knockdown

• Number of Nodes in the Network : 34
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 1.55796744394365e-08
• Fold Change Cut-Off : 2.12

Compared Group :

neocarzinostatin Vs untreated

• Number of Nodes in the Network : 50
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 3.92677384297713e-06
• Fold Change Cut-Off : 2.01

  Cockayne syndrome group B protein-null fibroblast rescue (HG-U133A)

GEO Description :
Analysis of Cockayne syndrome group B (CSB) protein-null fibroblasts rescued by expression of CSB cDNA. CS, a neurodegenerative disorder, arises mostly from CSB defects. Results provide insight into how CSB defects cause CS.
Organism : Homo sapiens
GEO-ID : GDS2175

Compared Group :

CSB wild type rescue Vs CSB mutant rescue

• Number of Nodes in the Network : 31
• Number of Nodes passing Cut-Off : 100
• PValue Cut-Off : 0.00178631232120097
• Fold Change Cut-Off : 2.06