'Pathway Search Results'

Selection criteria for significant gene list :: Significant genes are selected with a p value cut-off of 0.1. The resultant list was then sorted in a descending order of fold change value. From the sorted list, the top 100 genes were selected for pathway/network. If the gene list is less than 100, the entire gene list was taken for pathway/network analysis.

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>>Total hits : 49 , Search term given : Skin

UV irradiation effect on skin inactivated for tyrosine kinase receptor ErbB2: time course

GEO Description :
Analysis of the dorsal skin of animals treated with the tyrosine kinase receptor Erbb2 inhibitor AG825 and subsequently exposed to UV radiation. Skin examined 6 and 12 hours after UV irradiation. Results provide insight into the role of Erbb2 in the response to UV and in UV-induced pathologies.
Organism : Mus musculus
GEO-ID : GDS2139

Compared Group :
DMSO control Vs AG825

Number of Nodes in the Network : 28
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 0.00258821458555758
Fold Change Cut-Off : 2.07

Compared Group :
sham Vs UV

Number of Nodes in the Network : 31
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.67126007477592e-10
Fold Change Cut-Off : 2.1

Mechanical stress effect on fibroblasts from various fetal tissues (MG-430A)

GEO Description :
Expression profiling of fetal fibroblasts from tendon, skin, and cornea following mechanical stimulation by fluid flow. Fibroblasts isolated from embryos at 19 days post conception. Results provide insight into differences among fibroblasts from different tissues and response to linear shear stress.
Organism : Mus musculus
GEO-ID : GDS1500

Compared Group :
tendon fibroblast Vs skin fibroblast

Number of Nodes in the Network : 29
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 5.22209916198335e-07
Fold Change Cut-Off : 2.1

Hair follicle and skin molecular signatures

GEO Description :
Comparison of hair follicle matrix, outer root sheath, dermal papilla cells, melanocytes, and a dermal fraction enriched in fibroblasts were FACS-isolated from 4 day old Lef1-RFP/K14-H2BGFP backskins. Contributes to molecular dissection of mesenchymal-epithelial interactions in the hair follicle.
Organism : Mus musculus
GEO-ID : GDS1323

Compared Group :
matrix Vs melanocytes

Number of Nodes in the Network : 30
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 8.19275373942219e-05
Fold Change Cut-Off : 2.19

Compared Group :
outer root sheath Vs dermal papilla

Number of Nodes in the Network : 36
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 4.82661707792431e-05
Fold Change Cut-Off : 2.28

Compared Group :
melanocytes Vs dermal papilla

Number of Nodes in the Network : 43
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.69075447047362e-05
Fold Change Cut-Off : 2.3

Compared Group :
dermal fibroblasts Vs melanocytes

Number of Nodes in the Network : 37
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.12316429294879e-05
Fold Change Cut-Off : 2.07

Mechanical stimulation effect on fibroblasts from various fetal tissues (MG-430B)

GEO Description :
Expression profiling of fetal fibroblasts from tendon, skin, and cornea following mechanical stimulation by fluid flow. Fibroblasts isolated from embryos at 19 days post conception. Results provide insight into differences among fibroblasts from different tissues and response to linear shear stress.
Organism : Mus musculus
GEO-ID : GDS1501

Compared Group :
tendon fibroblast Vs skin fibroblast

Number of Nodes in the Network : 10
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 4.62175057691638e-06
Fold Change Cut-Off : 2.02

Hair follicle development: time course

GEO Description :
Expression profiling of back skin excised from CB6F1 animals at various ages up to 1 year. Difference between synchronously and asynchronously growing hair used to identify hair cycle genes. Results provide insight into the mechanisms regulating hair follicle morphogenesis.
Organism : Mus musculus
GEO-ID : GDS912

Compared Group :
14 d Vs 23 d

Number of Nodes in the Network : 30
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 1.29136024042964e-05
Fold Change Cut-Off : 2.27

Macular degeneration and dermal fibroblast response to sublethal oxidative stress

GEO Description :
Expression profiling of dermal fibroblasts from patients with macular degeneration. Fibroblasts subjected to sublethal oxidative stress. This study tests the hypothesis that patients with macular degeneration have an abnormal response to cellular injury in sites other than the eye.
Organism : Homo sapiens
GEO-ID : GDS963

Compared Group :
normal Vs macular degeneration

Number of Nodes in the Network : 48
Number of Nodes passing Cut-Off : 100
PValue Cut-Off : 2.73759730162748e-11
Fold Change Cut-Off : 2.64

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The interactions, networks, list of genes/molecules or any other information presented here, is HYPOTHETICAL in nature and is based on information collected from public as well as other sources, and is analyzed by certain automated mining and analysis software workflows. Strandlife Science Pvt.Ltd. or the Editors of PathwayWorld offer this information with NO CLAIMS of accuracy and WARRANTIES of any kind, and DO NOT Accept liability or legal responsibility for losses allegedly caused by using this information.

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